Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10962542 | Vaccine | 2016 | 7 Pages |
Abstract
Stimulation of splenocytes from immunized mice evidenced the presence of IFN-γ and IL-17-producing cells, indicated that OMVs induces both Th1 and Th17 response. Interestingly TdapOMVsBp-raised antibodies such as those induced by wP and commercial acellular vaccines (aP) which contribute to induce protection against Bordetella pertussis infection. As occurs with wP-induced antibodies, the TdapOMVsBp-induced serum antibodies efficiently opsonized B. pertussis. All the data here obtained shows that OMVs based vaccine is able to induce Th1/Th17 and Th2 mixed profile with robust humoral response involved in protection, positioning this candidate among the different possibilities to constitute the third generation of anti-pertussis vaccines.
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Authors
D. Bottero, M.E. Gaillard, E. Zurita, G. Moreno, D. Sabater Martinez, E. Bartel, S. Bravo, F. Carriquiriborde, A. Errea, C. Castuma, M. Rumbo, D. Hozbor,