Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10962624 | Vaccine | 2016 | 5 Pages |
Abstract
The efficacy of currently licensed anthrax vaccines is largely attributable to a single Bacillus anthracis immunogen, protective antigen. To broaden protection against possible strains resistant to protective antigen-based vaccines, we previously developed a vaccine in which the anthrax polyglutamic acid capsule was covalently conjugated to the outer membrane protein complex of Neisseria meningitidis serotype B and demonstrated that two doses of 2.5 μg of this vaccine conferred partial protection of rhesus macaques against inhalational anthrax . Here, we demonstrate complete protection of rhesus macaques against inhalational anthrax with a higher 50 μg dose of the same capsule conjugate vaccine. These results indicate that B. anthracis capsule is a highly effective vaccine component that should be considered for incorporation in future generation anthrax vaccines.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Donald J. Chabot, Wilson J. Ribot, Joseph Joyce, James Cook, Robert Hepler, Debbie Nahas, Jennifer Chua, Arthur M. Friedlander,