Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10963039 | Vaccine | 2015 | 7 Pages |
Abstract
Greater understanding of the factors associated with a protective response to influenza vaccine in older adults could have tremendous public health benefits. We studied 158 participants age 50-74 years vaccinated with 2010-2011 inactivated influenza vaccine and performed innate immunity and humoral immunity assays directed against influenza A/California/2009 (H1N1) as measured through hemagglutination inhibition (HAI), microneutralization, and B cell ELISPOT at days 0, 3, and 28 postvaccination. We report the results of statistical modeling using Day 3 cytokines, chemokines, and innate cell populations to model Day 0 to Day 28 HAI seroconversion, viral neutralization seroconversion, and B cell ELISPOT results.
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Authors
Richard B. Kennedy, Pritish K. Tosh, Krista M. Goergen, Diane E. Grill, Ann L. Oberg, Gregory A. Poland,