Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10963114 | Vaccine | 2015 | 9 Pages |
Abstract
The results provide evidence that MHC I-specific alloantibodies play a dominant role in the pathogenesis of BNP. Haematopoietic depletion was shown to be dependent on the titre and specificity of alloantibody produced by individual cows and the density of surface MHC I expression by different cell types. Collectively, the results support the hypothesis that MHC I molecules originating from MDBK cells used in vaccine production, coupled with a powerful adjuvant, are responsible for the generation of pathogenic alloantibodies.
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Immunology
Authors
Charlotte R. Bell, Niall D. MacHugh, Timothy K. Connelley, Kathryn Degnan, W. Ivan Morrison,