Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10963127 | Vaccine | 2015 | 6 Pages |
Abstract
The most frequent reaction was redness (19%), followed by induration, swelling, itching, and pain (6-12%); there were no serious adverse events. For some local reactions, multivariate analyses indicated associations of younger age, preschool attendance, presence of siblings, and allergy with lower risk, and use of thinner needles with higher risk. Most notably, administration of one or more IIV3 vaccines during the previous 3 seasons was positively associated with each local reaction (adjusted odds ratios: 3.6-5.4). For subjects aged â¥3 years, prior successive annual vaccinations were associated with substantially increased local reactions, with clear dose-response relationships (P for trend: <0.001 for each); for example, an 9.8-fold greater risk of swelling following three successive annual vaccinations before the study season.
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Authors
Chika Okada, Megumi Fujieda, Wakaba Fukushima, Satoko Ohfuji, Kyoko Kondo, Akiko Maeda, Takashi Nakano, Masaro Kaji, Yoshio Hirota, Influenza Vaccine Epidemiology Study Group Influenza Vaccine Epidemiology Study Group,