| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10963163 | Vaccine | 2015 | 6 Pages |
Abstract
An unexpectedly high proportion of healthy contacts of leprosy patients presented with PB leprosy within 12 weeks after receiving BCG vaccination, possibly as a result of boosted cell-mediated immunity by homologues of Mycobacterium leprae antigens in BCG. Various immunological mechanisms could underlie this phenomenon, including an immune reconstitution inflammatory syndrome (IRIS). Further studies are required to determine whether BCG vaccination merely altered the incubation period or actually changed the course of the infection from self-limiting, subclinical infection to manifest disease.
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Authors
Renate A. Richardus, C. Ruth Butlin, Khorshed Alam, Kallyan Kundu, Annemieke Geluk, Jan Hendrik Richardus,