Monophosphoryl lipid A coating of hydroxyethyl starch nanocapsules drastically increases uptake and maturation by dendritic cells while minimizing the adjuvant dosage

- Coating with the vaccine adjuvant MPLA onto hydroxyethyl starch nanocapsules promoted phagocytosis by human monocyte-derived dendritic cells and led to phenotypic maturation and the induction of IL-12 secretion as an indicator for a Th1-directed response.
- The applied dose of MPLA for the activation of moDCs could be reduced by immobilization onto the capsule surface indicating a dose reduction potential.