| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10963489 | Vaccine | 2015 | 9 Pages |
Abstract
The recombinant APCH I-tE21a-1b-2a vaccine was immunogenic both in guinea pigs and calves, inducing neutralizing antibodies. After BVDV type 1b and type 2 challenge of vaccinated calves in a proof of concept, the type 1b virus could not be isolated in any animal; meanwhile it was detected in all challenged non-vaccinated control animals. However, the type 2 BVDV was isolated to a lesser extent compared to unvaccinated animals challenged with type 2 BVDV. Clinical signs associated to BVDV, hyperthermia and leukopenia were reduced with respect to controls in all vaccinated calves. Given these results, this multivalent vaccine holds promise for a safe and effective tool to control BVDV in herds.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
A. Pecora, D.A. Malacari, M.S. Perez Aguirreburualde, D. Bellido, M.C. Nuñez, M.J. Dus Santos, J.M. Escribano, A. Wigdorovitz,