| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10963611 | Vaccine | 2015 | 5 Pages |
Abstract
Development of an effective AIDS vaccine is crucial for the control of global human immunodeficiency virus type 1 (HIV-1) prevalence. We have developed a novel AIDS vaccine using a Sendai virus (SeV) vector and investigated its efficacy in a macaque AIDS model of simian immunodeficiency virus (SIV) infection. Its immunogenicity and protective efficacy have been shown, indicating that the SeV vector is a promising delivery tool for AIDS vaccines. Here, we describe the potential of SeV vector as a vaccine antigen delivery tool to induce effective immune responses against HIV-1 infection.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Hiroshi Ishii, Tetsuro Matano,