Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10963634 | Vaccine | 2015 | 6 Pages |
Abstract
Animals of both groups developed inflammation of variable severity in the entire respiratory tract. Viral antigen positive cells were demonstrated in the nasal epithelium of both groups at day 2. The bronchi(oli) and alveoli of unprimed animals showed a moderate to strong positive signal at day 2, whereas H1N1pdm09-primed animals showed only minimal positivity. By day 7, only viral antigen positive cells were found after H7N9 virus infection in the nasal turbinates and the lungs of unprimed controls. Thus infection with H1N1pdm09 virus induced partially protective heterosubtypic immunity to H7N9 virus in (isogenic) guinea pigs that could not be attributed to cross-reactive virus neutralizing antibodies.
Keywords
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Authors
Lidewij C.M. Wiersma, Stella E. Vogelzang-van Trierum, Joost H.C.M. Kreijtz, Geert van Amerongen, Peter van Run, Mechtild Ladwig, Stefanie Banneke, Hubert Schaefer, Ron A.M. Fouchier, Thijs Kuiken, Albert D.M.E. Osterhaus, Guus F. Rimmelzwaan,