| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10964003 | Vaccine | 2015 | 6 Pages |
Abstract
Serum antibody to Mcat candidate vaccine proteins OMP CD, OppA, Msp22, Hag, and PilA2 increased with age in naturally immunized children age 6-30 months following Mcat NP colonization and AOM. High antibody levels against OppA, Msp22, and Hag correlated with reduced carriage. The results support further investigation of these vaccine candidates in protecting against Mcat colonization and infection.
Keywords
OMPOppAHAGNTHiMoraxella catarrhalisMIDMSPGAMSPNAOME. coliMEFmCATFBSNon-typeable Haemophilus influenzaeStreptococcus pneumoniaeNasopharyngeal colonizationEscherichia coliOropharyngealImmunogenicityanalysis of varianceANOVAELISAEnzyme-linked immunosorbent assayCarriageacute otitis mediafetal bovine serummonthsMiddle ear fluidGeneralized additive modelICHNasopharyngealhemagglutininVaccineAntigenOuter membrane proteinRecombinant proteinsInternational Conference on Harmonisation
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Authors
Dabin Ren, Anthony L. Almudevar, Timothy F. Murphy, Eric R. Lafontaine, Anthony A. Campagnari, Nicole Luke-Marshall, Janet R. Casey, Michael E. Pichichero,