| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10964471 | Vaccine | 2014 | 9 Pages |
Abstract
- Efficacy: Effective i.n. vaccination via DCs pulsed ex vivo with FcγR-targeted Ag is demonstrated.
- Immune responses: Mucosal, peripheral, humoral, and cellular immune responses are enhanced.
- Immune advantages: Traditional adjuvant is not required and inhibition via FcγRIIB is absent.
- Clinical advantages: Ability to use a less invasive i.n. route and stimulate CD4 and CD8 responses.
- Applications: Vaccines and therapeutics against chronic infectious diseases and cancer.
Keywords
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Immunology
Authors
Giang H. Pham, Bibiana V. Iglesias, Edmund J. Gosselin,