Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10964497 | Vaccine | 2015 | 9 Pages |
Abstract
These findings imply that HIV-1 vaccine strategies designed to target structurally constrained T-cell epitopes may be further challenged by clade-driven outcomes in specific HLA-restricted Gag epitopes. Equally, the data are line with slower HIV-1 disease progression in clade A infection; and raise hope that increased selective pressure on Gag may be protective irrespective of host HLA alleles.
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Authors
Jennifer Serwanga, Ritah Nakiboneka, Susan Mugaba, Brian Magambo, Nicaise Ndembi, Frances Gotch, Pontiano Kaleebu,