| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10964710 | Vaccine | 2015 | 9 Pages |
Abstract
Tetra DIIIC induced a Th1-type response against all four DENV serotypes and dengue-specific antibodies were predominantly IgG1 and IgG2a and neutralizing, while the induction of neutralizing antibodies was dependent on IFN signaling. Importantly, the Th1 and IgG1/IgG2a profile of the DIIIC vaccine approach is similar to an efficient natural anti-dengue response.
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Authors
Roland Zuest, Iris Valdes, David Skibinski, Yufang Lin, Ying Xiu Toh, Katherine Chan, Lisset Hermida, John Connolly, Gerardo Guillen, Katja Fink,