A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung

Article ID	Journal	Published Year	Pages	File Type
10965012	Vaccine	2014	7 Pages	PDF

Abstract

Overall, the present study showed the potential of the double-adjuvanted vaccine to induce systemic humoral immune responses in intratracheally vaccinated mice. Furthermore, it induced a strong mucosal immune response, with evidence of antigen-primed T-cells in the lung.

Keywords

c-di-GMP Hac1 Mucosal adjuvant Silica nanoparticle influenza vaccine plant-based

Related Topics

Life Sciences Immunology and Microbiology Immunology

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A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung

Authors

Vanessa Neuhaus, Jessica A. Chichester, Thomas Ebensen, Katharina Schwarz, Caitlin E. Hartman, Yoko Shoji, Carlos A. Guzmán, Vidadi Yusibov, Katherina Sewald, Armin Braun,