| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10965121 | Vaccine | 2015 | 8 Pages |
Abstract
The DC-TRN induced changes in the transcriptome were profound, lasting, and consisted of both protective signals and signatures of inflammation and immune exhaustion, with a net result of decreased viral load, without clinical benefit. Thus transcriptome analysis provides useful information, dissecting both positive and negative effects, for the evaluation of safety and efficacy of immunotherapeutic strategies.
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Authors
Anna L. de Goede, Arno C. Andeweg, Henk-Jan van den Ham, Maarten A. Bijl, Fatiha Zaaraoui-Boutahar, Wilfred F.J. van IJcken, Sofie Wilgenhof, Joeri L. Aerts, Rob A. Gruters, Albert D.M.E. Osterhaus,