| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10965365 | Vaccine | 2014 | 7 Pages |
Abstract
Adr2 is a protective antigen of R. rickettsii. Protection offered by Adr2 is mainly dependent on antigen-specific cell-mediated immune responses, including efficient activity of CD4+ and CD8+ T cells to produce great amount of TNF-α and/or IFN-γ as well as rapid increase of specific IgG2a, which synergistically activate and opsonize host cells to killing intracellular rickettsiae.
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Authors
Wenping Gong, Xiaolu Xiong, Yong Qi, Jun Jiao, Changsong Duan, Bohai Wen,