Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10965593 | Vaccine | 2014 | 12 Pages |
Abstract
Synthetic oligonucleotides (ODN) that express unmethylated “CpG motifs” trigger cells that express Toll-like receptor 9. In humans this includes plasmacytoid dendritic cells and B cells. CpG ODN induce an innate immune response characterized by the production of Th1 and pro-inflammatory cytokines. Their utility as vaccine adjuvants was evaluated in a number of clinical trials. Results indicate that CpG ODN improve antigen presentation and the generation of vaccine-specific cellular and humoral responses. This work provides an up-to-date overview of the utility of CpG ODN as adjuvants for vaccines targeting infectious agents and cancer.
Keywords
tNAPBMCCTLintradermalGMAISSGIAPMRAPCPFsGrowth inhibition assayAdjuvantProgression free survivaloverall survivalstable diseaseprogressive diseaseToll-like receptorIntravenousNot availablesubcutaneousCancerNSCLCNon-small cell lung cancerCytotoxic T cellDendritic cellNatural killer cellperipheral blood mononuclear cellsadverse eventIntramuscularInfectionHemagglutinin inhibitionAntibodyAntigenPartial responsecomplete responsePlasmodium falciparum
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Authors
Julia Scheiermann, Dennis M. Klinman,