Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10965777 | Vaccine | 2014 | 10 Pages |
Abstract
AERAS-402 was safe and immunogenic in healthy infants previously vaccinated with BCG at birth. Administration of the highest dose twice may be the most optimal vaccination strategy, based on the induced immunity. Multiple differences in T cell responses when infants are compared with adults vaccinated with AERAS-402, in the same setting and using the same whole blood intracellular cytokine assay, suggest specific strategies may be important for vaccination for each population.
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Authors
Benjamin M.N. Kagina, Michele D. Tameris, Hennie Geldenhuys, Mark Hatherill, Brian Abel, Gregory D. Hussey, Thomas J. Scriba, Hassan Mahomed, Jerald C. Sadoff, Willem A. Hanekom,