Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10965821 | Vaccine | 2013 | 9 Pages |
Abstract
This comparative analysis highlights the modulatory effect of antigen targeting on the resulting immune response, with a special emphasis on prophylactic anti-allergy DNA vaccination. Targeting the antigen to proteasomal or lysosomal degradation reduces the availability of native allergen, thereby rendering the vaccine hypoallergenic without compromising efficacy, an important feature for a therapeutic setting.
Keywords
Related Topics
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Immunology and Microbiology
Immunology
Authors
Esther E. Weinberger, Almedina Isakovic, Sandra Scheiblhofer, Christina Ramsauer, Katrin Reiter, Cornelia Hauser-Kronberger, Josef Thalhamer, Richard Weiss,