Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10965977 | Vaccine | 2013 | 9 Pages |
Abstract
- We engineered anti-influenza vaccine based on a VLP, adenoviral dodecahedron (Dd).
- Two M1 immunodominant epitopes were inserted in Dd without destroying its structure.
- DdM1 activated antigen-specific T cells responses in vitro.
- DdM1 induced cellular immunity in vivo in the absence of adjuvant.
Keywords
FCSpenton base proteinAd3Phorbol 12-myristate 13-acetate/ionomycinMoDCVLPAPCPBMCSPFPDCCTLAdenovirusamino acidantigen-presenting cellsHLACell-mediated immunityspecific pathogen-freeDodecahedronVirus-like particlefetal calf serumperipheral blood mononuclear cellsMonocyte-derived dendritic cellsplasmacytoid dendritic cellsphycoerythrincytotoxic T lymphocyteneuraminidasehemagglutinininfluenza vaccine
Related Topics
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Immunology and Microbiology
Immunology
Authors
Inga Szurgot, Ewa Szolajska, David Laurin, Benedicte Lambrecht, Laurence Chaperot, Guy Schoehn, Jadwiga Chroboczek,