Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10965998 | Vaccine | 2013 | 5 Pages |
Abstract
The aim of the study was to analyze the impact of MenBvac, an outer membrane vesicle (OMV) vaccine against P1.7,16 strains, on meningococcal carriage. During a B:14:P1.7,16/ST-32 outbreak in Normandy (France), children aged 1-7 years were randomly selected to participate in the study. Among the 1082 volunteers, there were 17 Neisseria meningitidis carriers (carriage rate of 1.57%). MenBvac vaccination appeared associated with lower carriage rate, i.e., 0.31% among the vaccinated children versus 2.10% among the non-vaccinated (p = 0.03). The beneficial effect on carriage was observed regardless of the strain serogroup. OMV-vaccinated mice also showed reduction of bacterial acquisition of OMV-homolog and hererolog strains in respiratory pathways after intranasal challenge. These results suggest that meningococcal OMV-based vaccines reduce meningococcal carriage and may hence confer herd immunity.
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Authors
Valérie Delbos, Ludovic Lemée, Jacques Bénichou, Gilles Berthelot, Ala-Eddine Deghmane, Jean-Philippe Leroy, Estelle Houivet, Eva Hong, Muhamed-Kheir Taha, François Caron, on behalf of the B14 STOP study group on behalf of the B14 STOP study group,