Immunological memory and nasopharyngeal carriage in 4-year-old children previously primed and boosted with 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) with or without concomitant prophylactic paracetamo

Article ID	Journal	Published Year	Pages	File Type
10966541	Vaccine	2013	9 Pages	PDF

Abstract

âº PHiD-CV immunisation with prophylactic paracetamol (PP) induced immune memory. âº Minor impact of previous PP on antibody persistence up to 3 years (y) post-booster. âº Nasopharyngeal carriage of vaccine serotypes reduced up to 3 y post-PHiD-CV booster. âº Previous PP seemed to have a limited impact on pneumococcal carriage rates. âº PP-altered lower PHiD-CV immunogenicity is probably of limited clinical relevance.

Keywords

OPA GlaxoSmithKline GMC SAE H. influenzae Moraxella catarrhalis S. pneumoniae GSK NPC GMT NPP NTHi cps MenACWY-TT PHiD-CV M. catarrhalis HRV Non-typeable Haemophilus influenzae ATP Staphylococcus aureus S. aureus Streptococcus pneumoniae standard deviation according-to-protocol Antibody persistence Immunological memory adverse event Serious adverse event confidence interval Opsonophagocytic activity Geometric mean titre Geometric mean concentration Blood sample Haemophilus influenzae Vaccine human rotavirus vaccine Pneumococcal conjugate vaccine polymerase chain reaction PCR Nasopharyngeal carriage Capsular polysaccharide PCV Vaccine efficacy