Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10966551 | Vaccine | 2013 | 5 Pages |
Abstract
We searched for an association between the interleukin 4 receptor gene (IL4R) rs1805015 and interleukin 13 gene (IL13) rs20541 polymorphisms and the development of antibodies to hepatitis B surface antigen (anti-HBs) in the case of hepatitis B virus (HBV) vaccination or infection in hemodialysis (HD) patients. HD patients who failed to respond to HBV vaccination did not differ in genotype frequencies of IL4R (TT 72.7%, CT 22.6%, CC 4.7%) and IL13 (CC 59.0%, CT 34.2%, TT 6.8%) from vaccine responders (IL4R TT 68.0%, CT 27.3%, CC 4.7%; IL13 CC 55.0%, CT 38.5%, TT 6.5%). HD patients who did not develop anti-HBs despite HBV infection also did not differ in genotype frequencies of IL4R (TT 67.8%, CT 26.8%, CC 5.4%) and IL13 (CC 60.7%, CT 33.9%, TT 5.4%) from HD patients who developed an anti-HBs response (IL4R TT 65.4%, CT 30.8%, CC 3.8%; IL13 CC 60.5%, CT 34.6%, TT 4.9%). In HD patients, neither the IL4R nor IL13 polymorphism is associated with anti-HBs development irrespective of whether an immunization is provoked by HBV vaccination or HBV infection.
Keywords
IL13ALTAntibodies to hepatitis C virusHBsAgRRTCMIAHRMIL4RGGTANCADNAASTAspartate aminotransferaseAlanine aminotransferaseanti-neutrophil cytoplasmic antibodiesmicroparticle enzyme immunoassaydeoxyribonucleic acidribonucleic acidRNAChemiluminescent microparticle immunoassayimmunoglobulin MEIAchronic kidney diseaserenal replacement therapyanti-HBcAnti-HBsAnti-HCVHBV infectionconfidence intervalnot applicableCKDodds ratioHemodialysisHBVHepatitis C virusHCVVaccinationhepatitis B virusSingle nucleotide polymorphismSNPgamma-glutamyltranspeptidase
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Authors
Alicja E. Grzegorzewska, Dominik Pajzderski, Anna SowiÅska, Adrianna Mostowska, PaweÅ P. JagodziÅski,