Article ID Journal Published Year Pages File Type
10966557 Vaccine 2013 7 Pages PDF
Abstract
► A DNA vaccine pCAGVP243 carrying VP243 gene of vvIBDV was evaluated in chickens. ► Plasmid pCAGVP243-IL-18 encoding both VP243 and chicken IL-18 was also constructed. ► Plasmid pCAGVP243-IL-18 induced higher levels of IBDV antibody than pCAGVP243. ► Plasmid pCAGVP243-IL-18 induced higher levels of IL-4 and IFN-γ than pCAGVP243. ► Plasmid pCAGVP243-IL-18 provided complete protection against vvIBDV challenge.
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Life Sciences Immunology and Microbiology Immunology
Preview
Adjuvant effects of interleukin-18 in DNA vaccination against infectious bursal disease virus in chickens
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