Leptin-based adjuvants: An innovative approach to improve vaccine response

Article ID	Journal	Published Year	Pages	File Type
10966708	Vaccine	2013	7 Pages	PDF

Abstract

âº Leptin deficiency/resistance impairs multiple immune functions. âº An attenuation of leptin signaling may be associated with vaccine failure. âº Chemical chaperones and inhibition of SOCS3 increase leptin sensitivity. âº Leptin-based adjuvant therapy may enhance vaccine response.

Keywords

mTOR UPR TLR TUDCA LEPR SOCS Hsp PBA PI3K PTP1B PBMC Protein-tyrosine phosphatase 1B Janus kinase natural killer MAPK ob/ob Adipokine STAT Adjuvant 4-phenylbutyric acid Tauroursodeoxycholic acid Infectious diseases Toll-like receptor db/db diabetic Peripheral blood mononuclear cell body mass index BMI endoplasmic reticulum Phosphatidylinositol 3-kinase Leptin Signal transducer and activator of transcription Obesity mammalian target of rapamycin Vaccine Unfolded protein response C-reactive protein CRP mitogen-activated protein kinase Heat shock proteins Obese JAK Leptin receptor