Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-Î³ T cell responses in humans

Article ID	Journal	Published Year	Pages	File Type
10966731	Vaccine	2013	7 Pages	PDF

Abstract

âº Oral immunization with rAd elicits Î³-IFN and granzyme B producing T cells in humans âº Granzyme B responses can be boosted with oral immunization âº Oral immunization with rAd has a positive safety profile âº Oral immunization with rAd does not elicit substantial anti-vector antibody responses.

Keywords

TLR RAD HAI dsRNA double-stranded RNA Recombinant adenovirus Avian influenza Influenza Toll-like receptor Intramuscular Mucosal i.m.hemagglutinin

Related Topics

Life Sciences Immunology and Microbiology Immunology

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Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-Î³ T cell responses in humans

Authors

Wendy Peters, Jennifer R. Brandl, Jonathan D. Lindbloom, C. Josefina Martinez, Ciaran D. Scallan, George R. Trager, Debora W. Tingley, Martin L. Kabongo, Sean N. Tucker,