Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10966741 | Vaccine | 2013 | 8 Pages |
Abstract
Two test vaccines were prepared under GMP: (1) A prototype E. coli CFA/I-only formalin-killed whole-cell + LCTBA vaccine, and (2) A “complete” inactivated multivalent ETEC-CF (CFA/I, CS3, CS5 and CS6 antigens) whole-cell + LCTBA vaccine. These vaccines, when given intragastrically alone or together with dmLT in mice, were well tolerated and induced strong intestinal-mucosal IgA antibody responses as well as serum IgG and IgA responses to each of the vaccine CF antigens as well as to LT B subunit (LTB). Both mucosal and serum responses were further enhanced (adjuvanted) when the vaccines were co-administered with dmLT. We conclude that the new multivalent oral ETEC vaccine, both alone and especially in combination with the dmLT adjuvant, shows great promise for further testing in humans.
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Authors
J. Holmgren, L. Bourgeois, N. Carlin, J. Clements, B. Gustafsson, A. Lundgren, E. Nygren, J. Tobias, R. Walker, A.-M. Svennerholm,