Article ID Journal Published Year Pages File Type
10966791 Vaccine 2013 7 Pages PDF
Abstract
► The alphavirus-based replicon vaccine strategy has advantages over other vaccines. ► PSMA-VRP is a propagation defective, viral replicon vector system encoding PSMA. ► A phase I first in human study of PSMA VRP in prostate cancer was safe. ► All subjects had immunologic competence noted by responses to standard mitogens. ► No cellular responses to PSMA was seen; few patients had a humoral response to PSMA.
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Related Topics
Life Sciences Immunology and Microbiology Immunology
Preview
A phase I dose escalation trial of vaccine replicon particles (VRP) expressing prostate-specific membrane antigen (PSMA) in subjects with prostate cancer
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