| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10966845 | Vaccine | 2012 | 6 Pages |
Abstract
⺠Intradermal delivery increases nicotine vaccine immunogenicity. ⺠Incorporation of safe adjuvants further increases nicotine vaccine immunogenicity. ⺠Peak anti-nicotine antibody titer persists longer in adjuvant-incorporated groups. ⺠Intradermal delivery plus adjuvants more efficiently prevents brain nicotine entry. ⺠We present a novel strategy to improve nicotine vaccine immunogenicity.
Keywords
TLRAPCOVALVAintradermalMPLPBSrEPAAlumantigen-presenting cellAdjuvantAddictionOvalbuminImmunogenicityimmunotherapyImiquimodanalysis of varianceANOVAIntradermal deliveryEnzyme-linked immunosorbent assayELISAToll-like receptorDendritic cellIntramuscularMonophosphoryl lipid APhosphate-buffered salineNicotine vaccine
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Authors
Xinyuan Chen, Marco Pravetoni, Brijesh Bhayana, Paul R. Pentel, Mei X. Wu,