| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10966867 | Vaccine | 2012 | 8 Pages |
Abstract
⺠We assessed immune memory in women vaccinated with the HPV-16/18 vaccine. ⺠These women received a 4th-dose of vaccine, 7 years after the primary vaccination. ⺠Pre 4th-dose, 100% of subjects remained seropositive for anti-HPV-16/18 antibodies. ⺠A 4th-dose triggered a rapid and strong anamnestic response in vaccinated women. ⺠Immune memory induced by the HPV-16/18 AS04-adjuvanted vaccine was demonstrated.
Keywords
NOCDIL-2IFN-γGMTTVCCMISAECVSLiPACD40LPBNADNAATPdeoxyribonucleic acidstandard deviationUnited Statescell-mediated immuneinterferon-gammainterleukin 2according-to-protocolELISAEnzyme-linked immunosorbent assayLine probe assaytumour necrosis factor-alphaCervical canceradverse eventHPV infectionSerious adverse eventconfidence intervalTNF-αCD40 ligandGeometric mean titreGeometric meanHPV vaccinepolymerase chain reactionPCRHuman papillomavirusHPVanamnestic responsetotal vaccinated cohort
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Authors
A.-B. Moscicki, C.M. Wheeler, B. Romanowski, J. Hedrick, S. Gall, D. Ferris, S. Poncelet, T. Zahaf, P. Moris, B. Geeraerts, D. Descamps, A. Schuind,