Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10966886 | Vaccine | 2013 | 8 Pages |
Abstract
Inhibin and follistatin are known to reduce fecundity by inhibiting the actions of activin and FSH. Thus, the immunoneutralization of these hormones is a rational proposal for augmenting reproductive performance. The present study describes a comprehensive computational methodology comprising of a consensus approach of several B- and Th-cell epitope prediction tools for the identification of epitopic regions within the structure of these hormones that can be incorporated into a poly-epitope fecundity vaccine. The proposed peptide (RGD-WSPAALRLLQRPPEEPA-KK-YSFPISSILE) should be effective in multiple animal species, generating good immunological memory.
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Authors
Bhaskar Ganguly, Sunil Kumar Rastogi, Shiv Prasad,