| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10966977 | Vaccine | 2013 | 7 Pages |
Abstract
⺠Investigated mechanism of FI-RSV-mediated vaccine-enhanced disease in cotton rats. ⺠Non-viral antigens in vaccine and challenge materials drive lung pathology. ⺠Clear association between alveolitis and cellular response to non-viral antigens. ⺠RSV antigens enhance alveolitis severity and cellular response to non-viral antigens. ⺠RSV and FI-RSV induce T cells specific for 3 peptide epitopes in RSV F.
Keywords
FI-RSVPBSPRSVT helper type 2Th2FBSIFNγRSVEMEMIL-4HRPERDBSAnot testedbovine serum albuminAlumInterleukin 4IntranasalELISAEagle's minimum essential mediumstandard error of the meanCotton ratfetal bovine serumIntramuscularPhosphate buffered salineSEMi.m.not significantaluminum hydroxideplaque forming unitsVaccineRespiratory syncytial virushorse radish peroxidasepfui.n.Interferon gammaheat inactivated
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Authors
Christine A. Shaw, Jean-Rene Galarneau, Kathryn E. Bowenkamp, Kurt A. Swanson, Gene A. Palmer, Giuseppe Palladino, Judit E. Markovits, Nicholas M. Valiante, Philip R. Dormitzer, Gillis R. Otten,