| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10966980 | Vaccine | 2013 | 8 Pages |
Abstract
⺠Biophysical characterization of the orthopoxvirus L1 vaccine antigen is presented. ⺠L1-protein adsorbed to Alhydrogel generated better IgG responses than non-adsorbed. ⺠Addition of CpG to Alhydrogel significantly enhances the anti-L1 antibody responses. ⺠L1 adsorbed to Alhydrogel resulted in better protection from vaccinia challenge. ⺠Vaccine formulation design is key to maximize vaccine immunogenicity and protection.
Keywords
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Authors
Yuhong Xiao, Yuhong Zeng, Edward Alexander, Shyam Mehta, Sangeeta B. Joshi, George W. Buchman, David B. Volkin, C. Russell Middaugh, Stuart N. Isaacs,