Anti-melanoma vaccinal capacity of CD11c-positive and -negative cell populations present in GM-CSF cultures derived from murine bone marrow precursors

► The population of DC obtained for vaccination, presents about 60% of CD11c+ DC. ► Only the heterogeneous vaccine (DC/ApoNec) was capable to induce protection. ► This protection seemed to be independent of the vaccine ability's to secrete IL-12. ► CD11c+ DC cells are not the only responsible for the protection achieved.