| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10966996 | Vaccine | 2013 | 7 Pages |
Abstract
⺠PfRH5 is essential for Plasmodium falciparum erythrocyte invasion. ⺠Antibodies raised against full-length functional PfRH5 potently blocked invasion. ⺠Five common PfRH5 polymorphisms were identified across 290 clinical isolates. ⺠Antibodies raised against one variant inhibited all other common PfRH5 variants. ⺠Correctly folded recombinant PfRH5 is a strong P. falciparum vaccine candidate.
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Authors
Leyla Y. Bustamante, S. Josefin Bartholdson, Cecile Crosnier, Marta G. Campos, Madushi Wanaguru, Chea Nguon, Dominic P. Kwiatkowski, Gavin J. Wright, Julian C. Rayner,