| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10967008 | Vaccine | 2013 | 8 Pages |
Abstract
⺠Sequence insertion at antigenic domain of HEV-VLP does not interfere with icosahedral assembly. ⺠Sequence insertion induces conformational changes at HEV antigenic domain leading to deterioration in antibody-binding. ⺠Sequence insertion introduces a trypsin cleavage site in the recombinant HEV capsid protein. ⺠The chimeric VLP remains intact after trypsin cleavage.
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Authors
Pitchanee Jariyapong, Li Xing, Nienke E. van Houten, Tian-Cheng Li, Wattana Weerachatyanukul, Benjamin Hsieh, Carlos G. Moscoso, Chun-Chieh Chen, Masahiro Niikura, R. Holland Cheng,