Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10967133 | Vaccine | 2013 | 6 Pages |
Abstract
Viral RNA loads decreased rapidly after birth; 19 out of 20 FI lambs that remained in the experiment until week 14 after birth, were RNA negative at that time. Since persistence of BTV-8 infection could not be demonstrated, we investigated whether foetal infection had an effect on protection against a field virus infection and on efficacy of vaccination. To this end, 5 FI lambs and 5 foetal non-infected (FNI) lambs were vaccinated with the inactivated Bovilis® BTV-8 vaccine, five months after birth. Three weeks after the vaccination, all lambs were infected with wild type BTV-8. The foetal infection did not interfere with vaccination efficacy. In contrast, foetal BTV-8 infection induced an immune response which afforded protection against BTV challenge comparable to the level of protection induced by vaccination.
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Authors
M.T.W. van der Sluijs, D.P.H. Schroer-Joosten, A. Fid-Fourkour, M. Smit, M.P. Vrijenhoek, V. Moulin, A.J. de Smit, R.J.M. Moormann,