Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10967332 | Vaccine | 2012 | 7 Pages |
Abstract
⺠Protocols of the histamine sensitization test (HIST) for measuring PTx in acellular pertussis vaccines were examined on a mouse model. ⺠Aged male mice were more sensitive to PTx than younger or female mice in HIST assays based on lethality or rectal temperature measurement. ⺠Sensitivity to PTx was further enhanced by the addition of LPS in the HIST. ⺠With these improvements PTx as low as 12.5 ng could be detected in both HIST assays.
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Authors
Hokyung Oh, Jeewon Joung, Byoung-Guk Kim, Kyung-Tak Nam, Seung-Hwa Hong, Hyun Chul Song, Ha-Lim Lee, Byung-Yoon Ahn,