Article ID Journal Published Year Pages File Type
10967343 Vaccine 2012 8 Pages PDF
Abstract
► We examine the effects of DNA vaccine by electroporation (i.m.). ► DNA vaccine induces antigen-specific CD8+ T cells, and mucosal antigen-specific CD8+ T cells express gut-homing molecule, α4β7 integrin or αE integrin. ► The antigen-specific CD8+ T cells produce multiple cytokines. ► DNA vaccine induces antibody (IgA and IgG) in systemic and gut-mucosal compartment. ► DNA vaccine can induce cellular and humoral immune response in both systemic and gut-mucosal compartments.
Keywords
Related Topics
Life Sciences Immunology and Microbiology Immunology
Preview
Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments
Authors
, , , , , , ,