| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10967517 | Vaccine | 2012 | 7 Pages |
Abstract
⺠Rg1 and Re have adjuvant activity in C3H/HeB mice, but not in C3H/HeJ mice. ⺠Rg1 and Re induce expression of NF-κB in macrophages. ⺠Blocking TLR4 on cells with anti-TLR4 IgG inhibits Re- but not Rg1-induced NF-κB. ⺠Rg1 triggers extra- and intra-cellular TLR4 while Re triggers extra-cellular TLR4. ⺠TLR4 is supposed to be involved in the adjuvant activities of Rg1 and Re.
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Authors
Fei Su, Lin Yuan, Lijia Zhang, Songhua Hu,