| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10967820 | Vaccine | 2012 | 7 Pages |
Abstract
⺠We found that the HA of 2009 H1N1 A/CA/09 virus could not be cleaved by bromelain for antiserum production. ⺠We generated a chimeric virus to make the HA cleavable by bromelain. ⺠We demonstrated that chimeric HA was immunogenic and protective. ⺠We determined the molecular mechanism of HA cleavage. ⺠We showed that amino acids at positions 373 and 374 of the HA are critical for HA bromelain cleavage.
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Authors
Weijia Wang, Amorsolo L. Jr., James Zengel, Zhongying Chen, Hong Jin,