| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10967841 | Vaccine | 2012 | 11 Pages |
Abstract
⺠Yeast Pichia pastoris produced cholera toxin B subunit (CTB) as a glycoprotein. ⺠Oligosaccharide (OS) extends from the lateral circumference of the CTB pentamer ring. ⺠The OS chain was exploited as an anchoring scaffold for a malaria antigen (MSP1). ⺠MSP1 fused via the OS chain induced increased protection against malaria infection. ⺠Increased protection was due to higher Ag loading capacity of the CTB glycoprotein.
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Authors
Takeshi Miyata, Tetsuya Harakuni, Toki Taira, Goro Matsuzaki, Takeshi Arakawa,