| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10967881 | Vaccine | 2013 | 10 Pages |
Abstract
⺠Transcutaneous immunization with chimV4+ dmLT resolved ongoing NTHI-induced experimental OM. ⺠Significant reduction in signs of OM, NTHI concentration and mucosal biofilms in the middle ear was achieved. ⺠Activated DCs, polyfunctional T-cells and host defense peptide contributed to rapid resolution. ⺠Immunogen-specific IgG in middle ear fluids also contributed to eradication of NTHI. ⺠Transcutaneous immunization is a simple strategy to induce efficacious immune responses.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Laura A. Novotny, John D. Clements, Lauren O. Bakaletz,