| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10967888 | Vaccine | 2013 | 10 Pages |
Abstract
⺠We investigated transfollicular vaccination via intact skin using nanoparticles(NP). ⺠Polymeric NP from PLGA+- chitosan were loaded with ovalbumin (OVA). ⺠OVA/NP stimulated proliferation of CD4+ &/or CD8+ T-cells more than OVA/solution. ⺠NP improved (Ã2-3) follicular delivery of OVA on pig ears compared to OVA/solution. ⺠Consequently using OVA/NP one may reduce the dose compared to OVA/solution.
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Authors
Ankit Mittal, Anne S. Raber, Ulrich F. Schaefer, Sebastian Weissmann, Thomas Ebensen, Kai Schulze, Carlos A. Guzmán, Claus-Michael Lehr, Steffi Hansen,