| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10967952 | Vaccine | 2012 | 7 Pages |
Abstract
⺠This novel study quantifies the effect of DNA topology on polyplex uptake in DCs. ⺠Polyplex uptake was monitored by microscopy and gene expression assays. ⺠Complexes containing supercoiled DNA associated most efficiently with DC nuclei. ⺠Gene expression showed quantitative dependence on DNA topology. ⺠DC phenotype was independent of DNA topology.
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Authors
Arjun Dhanoya, Benjamin M. Chain, Eli Keshavarz-Moore,