| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10967999 | Vaccine | 2012 | 11 Pages |
Abstract
⺠Vaccination against Staphylococcus aureus is achieved with toxoids. ⺠Toxoids are >107 inactivated and stimulate immunity to S. aureus. ⺠Superantigen toxoids exhibit adjuvant activity dependent on immune co-stimulatory molecule CD40 binding activity. ⺠Protective neutralizing antibodies are produced in rabbits to toxic shock syndrome toxin-1.
Keywords
CFUsTSST-1SuperantigenKSFMTSSLPSPBSmethicillin-resistant S. aureusStaphylococcus aureusMRSASDS-PAGESodium dodecyl sulfate polyacrylamide gel electrophoresisStaphylococcal enterotoxintoxic shock syndromeCytolysinlipopolysaccharideMHCmajor histocompatibility complexPhosphate-buffered salineRabbit modelcolony-forming unitsVaccinekeratinocyte serum-free medium
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Authors
Adam R. Spaulding, Ying-Chi Lin, Joseph A. Merriman, Amanda J. Brosnahan, Marnie L. Peterson, Patrick M. Schlievert,