| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10968010 | Vaccine | 2012 | 13 Pages |
Abstract
⺠New, second-generation live attenuated Shigella flexneri 2a vaccine candidates. ⺠WRSf2G12 and WRSf2G15 are as invasive as parental strain 2457T in HeLa cells. ⺠WRSf2G12 and WRSf2G15 are Sereny negative and protective in guinea pigs. ⺠WRSf2G15 that lacks the MsbB2 gene has lower endotoxicity profile in macrophages. ⺠A 3 vs. 2 dose immunization regimen provides better protection in guinea pigs.
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Authors
Ryan T. Ranallo, Suramya Fonseka, Tara L. Boren, Lisa A. Bedford, Robert W. Kaminski, Sejal Thakkar, Malabi M. Venkatesan,