Enhanced humoral and mucosal immune responses after intranasal immunization with chimeric multiple antigen peptide of LcrV antigen epitopes of Yersinia pestis coupled to palmitate in mice

► F1 and V antigens are putative plague vaccine candidates V antigen is the major vaccine candidate. ► Sub-unit vaccines/peptide vaccines can be synthesized, unwanted or suppressor regions can be eliminated and sequence is known. ► Different epitopes can be included in chimeric multiple antigenic peptide and can be delivered intranasally. ► Intranasal route of immunization can elicit both systemic as well as mucosal humoral immune responses.