| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10968148 | Vaccine | 2011 | 7 Pages |
Abstract
⺠Extracellular domains of CEA and HER2 as adenoviral exosome expressed proteins. ⺠Infection of cells enables expression of CEA and HER2 in secreted exosomes. ⺠Exosome expressed CEA and HER2 stimulate enhanced immune responses. ⺠Vaccination with exosomal HER2 adenovirus enhances anti-tumor responses in vivo.
Keywords
HER2TAACDCBMDCECDMVBMUC1APCCeAcarcinoembryonic antigenTumor antigenstumor associated antigensAntigen presenting cellsExosomesmultivesicular bodiesAdenovirus vectorsextracellular domainbone marrow derived dendritic cellscomplement-dependent cytotoxicityMucin 1Cancer vaccinesHuman epidermal growth factor receptor 2
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Authors
Zachary C. Hartman, Junping Wei, Oliver K. Glass, Hongtao Guo, Gangjun Lei, Xiao-Yi Yang, Takuya Osada, Amy Hobeika, Alain Delcayre, Jean-Bernard Le Pecq, Michael A. Morse, Timothy M. Clay, Herbert K. Lyerly,